Spectroscopy
- FTIR
- UV-VIS
- NIR
Chromatography
- HPLC (UV, DAD, Fluorescence, MS)
- Semi-preparative HPLC for separation of substances for structure determination and method development
- GC (FID)
- GC-Headspace
- TLC
Miscellaneous pharmacopeia standard tests (PharmEur, USP), i.e.
- water determination (Karl-Fischer, titrimetric)
- optical rotation
- loss on drying
- sulphated ash/ residue on ignition
- melting point
General API property determination such as solubilities, pKa, log P, permeability etc. (CTD module 3 chapter 3.2.S.1.3 and IMPD 2.2.1.S.1.3)
Solid-State Characterisation
- DSC (differential scanning calorimetry)
- microscopy / thermomicroscopy / imaging analysis
- Particle size distribution by laser diffraction (wet / dry dispersion)
- Crystal density (gas pycnometry)
- determination of special solid state parameters such as aggregate density, dispersion analysis, sedimentation / flocculation analysis
- XRPD*
- RAMAN methods*
- BET (surface determination)*
- iGC (inverse GC)*
*External methods
Further methods on request